scientist

Publications

Jul
30
2020
Bacteria-eating viruses could provide a route to stability in cystic fibrosis: Phage therapy is broadening the treatment landscape for people with drug-resistant infections.
Svoboda E.
Nature 583(7818):S8-S9. doi: 10.1038/d41586-020-02109-7.
Feb
17
2020
Safety of Bacteriophage Therapy in Severe Staphylococcus aureus Infection.
Fabijan AP, Lin RCY, Ho J, Maddocks S, Ben Zakour NL, Iredell JR, Westmead Bacteriophage Therapy Team.
Nat Microbiol 5, 465–472 (2020).
Nov
01
2019
Bacteriophage Therapy of Ventilator-associated Pneumonia and Empyema Caused by Pseudomonas aeruginosa.
Maddocks S, Fabijan AP, Ho J, Lin RCY, Ben Zakour NL, Dugan C, Kliman I, Branston S, Morales S, Iredell JR.
Am J Respir Crit Care Med. 2019 Nov 1;200(9):1179-1181.
Jul
08
2019
Adjunctive bacteriophage therapy for prosthetic valve endocarditis due to Staphylococcus aureus.
Gilbey T, Ho Josephine, Cooley LA, Fabijan AP, Iredell JI.
Med J Aust. 2019 Aug;211(3):142-143.e1. Epub 2019 Jul 8.
Jun
20
2019
Safety and Tolerability of Bacteriophage Therapy for Chronic Rhinosinusitis Due to Staphylococcus aureus.
Ooi ML, Drilling AJ, Morales S, Fong S, Moraitis S, Macias-Valle L, Vreugde S, Psaltis AJ, Wormald PJ.
JAMA Otolaryngol Head Neck Surg. 2019 Jun 20.
May
17
2019
Successful adjunctive use of bacteriophage therapy for treatment of multidrug‑resistant Pseudomonas aeruginosa infection in a cystic fibrosis patient.
Law N, Logan C, Yung G, Furr CL, Lehman SM, Morales S, Rosas F, Gaidamaka A, Bilinsky I, Grint P, Schooley RT, Aslam S.
Infection. 2019 Aug;47(4):665-668. Epub 2019 May 17.
Jan
12
2019
Design and Preclinical Development of a Phage Product for the Treatment of Antibiotic-Resistant Staphylococcus aureus Infections.
Lehman SM, Mearns G, Rankin D, Cole RA, Smrekar F, Branston SD, Morales S.
Viruses. 2019 Jan 21;11(1), 88.
Jan
07
2019
Novel bacteriophage therapy for treatment of left ventricular assist device infection.
Aslam S, Pretorius V, Lehman SM, Morales S, Schooley RT.
J Heart Lung Transplant. 2019 Jan 7. pii: S1053-2498(19)30001-4.
Dec
19
2018
Safety and efficacy of a bacteriophage cocktail in an in vivo model of Pseudomonas aeruginosa sinusitis.
Fong SA, Drilling AJ, Ooi ML, Paramasivan S, Finnie JW, Morales S, Psaltis AJ, Vreugde S, Wormald PJ.
Transl Res. 2018 Dec 19.
Nov
26
2018
Safety and Efficacy of Bacteriophage Therapy: Analysis of Clinical Case Series Data.
Aslam, S., Gilbey, T., Maddocks, S., Morales, S., Lehman, S., Branston, S., Fabijan, A.P., Furr, C-L.L., Rosas, F., Bilinsky, I., Grint, P., Schooley, R.T., and Iredell, J.
Open Forum Infectious Diseases. 2018 5(suppl_1): S47.
Sep
01
2018
Chapter 7: Bacteriophage Diversity.
Lehman, S.M. 2018.
pp 145-165 In Viruses of Microorganisms: Diversity and Applications, Caister Academic Press, Norwich UK.
Aug
01
2018
Phage therapy for respiratory infections.
Chang RYK, Wallin M, Lin Y, Leung SSY, Wang H, Morales S, Chan HK.
Adv Drug Deliv Rev. 2018 Aug;133:76-86.
Jun
01
2018
Differential gene expression by Pseudomonas aeruginosa in response to bacteriophage infection.
Brugha, R., Martin, I., Morales, S., Lehman, S., Alton, E., and J. Davies.
Journal of Cystic Fibrosis, 2018 17: S69.
Mar
01
2018
Bacteriophage effectively kills multidrug resistant Staphylococcus aureus clinical isolates from chronic rhinosinusitis patients.
Zhang G, Zhao Y, Paramasivan S, Richter K, Morales S, Wormald PJ, Vreugde S.
Int Forum Allergy Rhinol. 2018 Mar;8(3):406-414.
Sep
22
2017
Activity of Bacteriophages in Removing Biofilms of Pseudomonas aeruginosa Isolates from Chronic Rhinosinusitis Patients.
Fong SA, Drilling A, Morales S, Cornet ME, Woodworth BA, Fokkens WJ, Psaltis AJ, Vreugde S, Wormald PJ.
Front Cell Infect Microbiol. 2017 Sep 22;7:418.
Aug
01
2017
Correlation between phenotypic antibiotic susceptibility and the resistome in Pseudomonas aeruginosa.
Jaillard M, van Belkum A, Cady KC, Creely D, Shortridge D, Blanc B, Barbu EM, Dunne WM Jr, Zambardi G, Enright M, Mugnier N, Le Priol C, Schicklin S, Guigon G, Veyrieras JB.
Int J Antimicrob Agents. 2017 Aug;50(2):210-218.
Jul
07
2017
Bacteriophage therapy for refractory Pseudomonas aeruginosa urinary tract infection.
Khawaldeh A, Morales S, Dillon B, Alavidze Z, Ginn AN, Thomas L, Chapman SJ, Dublanchet A, Smithyman A, Iredell JR.
J Med Microbiol. 2011 Nov;60(Pt 11):1697-700.
Oct
03
2016
Phage Therapy in the Era of Synthetic Biology.
Barbu EM, Cady KC, Hubby B.
Cold Spring Harb Perspect Biol. 2016 Oct 3;8(10).
May
13
2016
Pseudomonas aeruginosa infection in cystic fibrosis: pathophysiological mechanisms and therapeutic approaches.
Lund-Palau H, Turnbull AR, Bush A, Bardin E, Cameron L, Soren O, Wierre-Gore N, Alton EW, Bundy JG, Connett G, Faust SN, Filloux A, Freemont P, Jones A, Khoo V, Morales S, Murphy R, Pabary R, Simbo A, Schelenz S, Takats Z, Webb J, Williams HD, Davies JC.
Expert Rev Respir Med. 2016 Jun;10(6):685-97.
Nov
24
2015
Phylogenetic Distribution of CRISPR-Cas Systems in Antibiotic-Resistant Pseudomonas aeruginosa.
van Belkum A, Soriaga LB, LaFave MC, Akella S, Veyrieras JB, Barbu EM, Shortridge D, Blanc B, Hannum G, Zambardi G, Miller K, Enright MC, Mugnier N, Brami D, Schicklin S, Felderman M, Schwartz AS, Richardson TH, Peterson TC, Hubby B, Cady KC.
MBio. 2015 Nov 24;6 (6): e01796-15.
Nov
16
2015
Antipseudomonal Bacteriophage Reduces Infective Burden and Inflammatory Response in Murine Lung.
Pabary R, Singh C, Morales S, Bush A, Alshafi K, Bilton D, Alton EW, Smithyman A, Davies JC.
Antimicrobial Agents Chemother. 2015 Nov 16;60(2):744-51.
Jun
25
2014
Bacteriophages and Biofilms.
Harper, D.R., Parracho, H.M., Walker, J., Sharp, R., Hughes, G., Werthen, M., Lehman, S.M., Morales, S.
Antibiotics 2014 3(3):270-284.
Jan
21
2014
Safety and efficacy of topical bacteriophage and ethylenediaminetetraacetic acid treatment of Staphylococcus aureus infection in a sheep model of sinusitis.
Drilling A, Morales S, Boase S, Jervis-Bardy J, James C, Jardeleza C, Tan NC, Cleland E, Speck P, Vreugde S, Wormald PJ.
Int Forum Allergy Rhinol. 2014 Mar;4(3):176-86.
Jan
01
2014
Bacteriophage reduces biofilm of Staphylococcus aureus ex vivo isolates from chronic rhinosinusitis patients.
Drilling A, Morales S, Jardeleza C, Vreugde S, Speck P, Wormald PJ.
Am J Rhinol Allergy. 2014 Jan-Feb;28(1):3-11.
Dec
01
2012
Bacteriophages are synergistic with bacterial interference for the prevention of Pseudomonas aeruginosa biofilm formation on urinary catheters.
Liao, K. S., Lehman, S.M., Tweardy, D.J., Donlan, R.M., and Trautner, B.W.
Journal of Applied Microbiology. 2012 113:1530-1539.
Jul
01
2012
Bacteriophage therapy: practicability and clinical need meet in the multidrug-resistance era.
Harper DR, Morales S.
Future Microbiol. 2012 Jul;7(7):797-9.