Publications - Armata Pharmaceuticals

Jul

2020

Bacteria-eating viruses could provide a route to stability in cystic fibrosis: Phage therapy is broadening the treatment landscape for people with drug-resistant infections.

Svoboda E.

Nature 583(7818):S8-S9. doi: 10.1038/d41586-020-02109-7.

Feb

2020

Safety of Bacteriophage Therapy in Severe Staphylococcus aureus Infection.

Fabijan AP, Lin RCY, Ho J, Maddocks S, Ben Zakour NL, Iredell JR, Westmead Bacteriophage Therapy Team.

Nat Microbiol 5, 465–472 (2020).

Nov

2019

Bacteriophage Therapy of Ventilator-associated Pneumonia and Empyema Caused by Pseudomonas aeruginosa.

Maddocks S, Fabijan AP, Ho J, Lin RCY, Ben Zakour NL, Dugan C, Kliman I, Branston S, Morales S, Iredell JR.

Am J Respir Crit Care Med. 2019 Nov 1;200(9):1179-1181.

Jul

2019

Adjunctive bacteriophage therapy for prosthetic valve endocarditis due to Staphylococcus aureus.

Gilbey T, Ho Josephine, Cooley LA, Fabijan AP, Iredell JI.

Med J Aust. 2019 Aug;211(3):142-143.e1. Epub 2019 Jul 8.

Jun

2019

Safety and Tolerability of Bacteriophage Therapy for Chronic Rhinosinusitis Due to Staphylococcus aureus.

Ooi ML, Drilling AJ, Morales S, Fong S, Moraitis S, Macias-Valle L, Vreugde S, Psaltis AJ, Wormald PJ.

JAMA Otolaryngol Head Neck Surg. 2019 Jun 20.

May

2019

Successful adjunctive use of bacteriophage therapy for treatment of multidrug‑resistant Pseudomonas aeruginosa infection in a cystic fibrosis patient.

Law N, Logan C, Yung G, Furr CL, Lehman SM, Morales S, Rosas F, Gaidamaka A, Bilinsky I, Grint P, Schooley RT, Aslam S.

Infection. 2019 Aug;47(4):665-668. Epub 2019 May 17.

Jan

2019

Design and Preclinical Development of a Phage Product for the Treatment of Antibiotic-Resistant Staphylococcus aureus Infections.

Lehman SM, Mearns G, Rankin D, Cole RA, Smrekar F, Branston SD, Morales S.

Viruses. 2019 Jan 21;11(1), 88.

Jan

2019

Novel bacteriophage therapy for treatment of left ventricular assist device infection.

Aslam S, Pretorius V, Lehman SM, Morales S, Schooley RT.

J Heart Lung Transplant. 2019 Jan 7. pii: S1053-2498(19)30001-4.

Dec

2018

Safety and efficacy of a bacteriophage cocktail in an in vivo model of Pseudomonas aeruginosa sinusitis.

Fong SA, Drilling AJ, Ooi ML, Paramasivan S, Finnie JW, Morales S, Psaltis AJ, Vreugde S, Wormald PJ.

Transl Res. 2018 Dec 19.

Nov

2018

Safety and Efficacy of Bacteriophage Therapy: Analysis of Clinical Case Series Data.

Aslam, S., Gilbey, T., Maddocks, S., Morales, S., Lehman, S., Branston, S., Fabijan, A.P., Furr, C-L.L., Rosas, F., Bilinsky, I., Grint, P., Schooley, R.T., and Iredell, J.

Open Forum Infectious Diseases. 2018 5(suppl_1): S47.

Sep

2018

Chapter 7: Bacteriophage Diversity.

Lehman, S.M. 2018.

pp 145-165 In Viruses of Microorganisms: Diversity and Applications, Caister Academic Press, Norwich UK.

Aug

2018

Phage therapy for respiratory infections.

Chang RYK, Wallin M, Lin Y, Leung SSY, Wang H, Morales S, Chan HK.

Adv Drug Deliv Rev. 2018 Aug;133:76-86.

Jun

2018

Differential gene expression by Pseudomonas aeruginosa in response to bacteriophage infection.

Brugha, R., Martin, I., Morales, S., Lehman, S., Alton, E., and J. Davies.

Journal of Cystic Fibrosis, 2018 17: S69.

Mar

2018

Bacteriophage effectively kills multidrug resistant Staphylococcus aureus clinical isolates from chronic rhinosinusitis patients.

Zhang G, Zhao Y, Paramasivan S, Richter K, Morales S, Wormald PJ, Vreugde S.

Int Forum Allergy Rhinol. 2018 Mar;8(3):406-414.

Sep

2017

Activity of Bacteriophages in Removing Biofilms of Pseudomonas aeruginosa Isolates from Chronic Rhinosinusitis Patients.

Fong SA, Drilling A, Morales S, Cornet ME, Woodworth BA, Fokkens WJ, Psaltis AJ, Vreugde S, Wormald PJ.

Front Cell Infect Microbiol. 2017 Sep 22;7:418.

Aug

2017

Correlation between phenotypic antibiotic susceptibility and the resistome in Pseudomonas aeruginosa.

Jaillard M, van Belkum A, Cady KC, Creely D, Shortridge D, Blanc B, Barbu EM, Dunne WM Jr, Zambardi G, Enright M, Mugnier N, Le Priol C, Schicklin S, Guigon G, Veyrieras JB.

Int J Antimicrob Agents. 2017 Aug;50(2):210-218.

Jul

2017

Bacteriophage therapy for refractory Pseudomonas aeruginosa urinary tract infection.

Khawaldeh A, Morales S, Dillon B, Alavidze Z, Ginn AN, Thomas L, Chapman SJ, Dublanchet A, Smithyman A, Iredell JR.

J Med Microbiol. 2011 Nov;60(Pt 11):1697-700.

Oct

2016

Phage Therapy in the Era of Synthetic Biology.

Barbu EM, Cady KC, Hubby B.

Cold Spring Harb Perspect Biol. 2016 Oct 3;8(10).

May

2016

Pseudomonas aeruginosa infection in cystic fibrosis: pathophysiological mechanisms and therapeutic approaches.

Lund-Palau H, Turnbull AR, Bush A, Bardin E, Cameron L, Soren O, Wierre-Gore N, Alton EW, Bundy JG, Connett G, Faust SN, Filloux A, Freemont P, Jones A, Khoo V, Morales S, Murphy R, Pabary R, Simbo A, Schelenz S, Takats Z, Webb J, Williams HD, Davies JC.

Expert Rev Respir Med. 2016 Jun;10(6):685-97.

Nov

2015

Phylogenetic Distribution of CRISPR-Cas Systems in Antibiotic-Resistant Pseudomonas aeruginosa.

van Belkum A, Soriaga LB, LaFave MC, Akella S, Veyrieras JB, Barbu EM, Shortridge D, Blanc B, Hannum G, Zambardi G, Miller K, Enright MC, Mugnier N, Brami D, Schicklin S, Felderman M, Schwartz AS, Richardson TH, Peterson TC, Hubby B, Cady KC.

MBio. 2015 Nov 24;6 (6): e01796-15.

Nov

2015

Antipseudomonal Bacteriophage Reduces Infective Burden and Inflammatory Response in Murine Lung.

Pabary R, Singh C, Morales S, Bush A, Alshafi K, Bilton D, Alton EW, Smithyman A, Davies JC.

Antimicrobial Agents Chemother. 2015 Nov 16;60(2):744-51.

Jun

2014

Bacteriophages and Biofilms.

Harper, D.R., Parracho, H.M., Walker, J., Sharp, R., Hughes, G., Werthen, M., Lehman, S.M., Morales, S.

Antibiotics 2014 3(3):270-284.

Jan

2014

Safety and efficacy of topical bacteriophage and ethylenediaminetetraacetic acid treatment of Staphylococcus aureus infection in a sheep model of sinusitis.

Drilling A, Morales S, Boase S, Jervis-Bardy J, James C, Jardeleza C, Tan NC, Cleland E, Speck P, Vreugde S, Wormald PJ.

Int Forum Allergy Rhinol. 2014 Mar;4(3):176-86.

Jan

2014

Bacteriophage reduces biofilm of Staphylococcus aureus ex vivo isolates from chronic rhinosinusitis patients.

Drilling A, Morales S, Jardeleza C, Vreugde S, Speck P, Wormald PJ.

Am J Rhinol Allergy. 2014 Jan-Feb;28(1):3-11.

Dec

2012

Bacteriophages are synergistic with bacterial interference for the prevention of Pseudomonas aeruginosa biofilm formation on urinary catheters.

Liao, K. S., Lehman, S.M., Tweardy, D.J., Donlan, R.M., and Trautner, B.W.

Journal of Applied Microbiology. 2012 113:1530-1539.

Jul

2012

Bacteriophage therapy: practicability and clinical need meet in the multidrug-resistance era.

Harper DR, Morales S.

Future Microbiol. 2012 Jul;7(7):797-9.